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Article

Modelling APOE ɛ3/4 allele-associated sporadic Alzheimer's disease in an induced neuron.

Brain : a journal of neurology - 1 Aug 2017

Kim Hongwon, Yoo Junsang, Shin Jaein, Chang Yujung, Jung Junghyun, Jo Dong-Gyu, Kim Janghwan, Jang Wonhee, Lengner Christopher J, Kim Byung-Soo, Kim Jongpil

Abstract excerpt

The recent generation of induced neurons by direct lineage conversion holds promise for in vitro modelling of sporadic Alzheimer's disease. Here, we report the generation of induced neuron-based model of sporadic Alzheimer's disease in mice and humans, and used this system to explore the pathogenic mechanisms resulting from the sporadic Alzheimer's disease risk factor apolipoprotein E (APOE) ɛ3/4 allele. We show...

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Source

Identifiers

PMID: 28899010
DOI: 10.1093/brain/awx144

Genes

APOE
APP
DSG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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