Article
The parathyroid hormone regulates skin tumour susceptibility in mice.
Scientific reports - 11 Sept 2017
Okumura Kazuhiro, Saito Megumi, Yoshizawa Yasuhiro, Munakata Haruka, Isogai Eriko, Miura Ikuo, Wakana Shigeharu, Yamaguchi Midori, Shitara Hiroshi, Taya Choji, Karaplis Andrew C, Kominami Ryo, Wakabayashi Yuichi
Abstract excerpt
Using a forward genetics approach to map loci in a mouse skin cancer model, we previously identified a genetic locus, Skin tumour modifier of MSM 1 (Stmm1) on chromosome 7, conferring strong tumour resistance. Sub-congenic mapping localized Parathyroid hormone (Pth) in Stmm1b. Here, we report that serum intact-PTH (iPTH) and a genetic polymorphism in Pth are important for skin tumour resistance. We identified...
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