Article
Small Molecule Inhibitors of the Hedgehog Pathway in the Treatment of Basal Cell Carcinoma of the Skin.
American journal of clinical dermatology - 1 Apr 2018
Danhof Rebecca, Lewis Karl, Brown Mariah
Abstract excerpt
Basal cell carcinoma (BCC) is the most common type of skin cancer, with rising incidence rates primarily attributed to an aging population and ultraviolet radiation exposure. While the majority of BCCs are localized and respond to standard therapies, a very small minority of these tumors become locally destructive or metastasize. These advanced BCCs may not be amenable to localized treatment with surgery and/or...
Topics
- Anilides
- Antineoplastic Agents
- Biphenyl Compounds
- Carcinoma, Basal Cell
- Clinical Trials as Topic
- Drug Resistance, Neoplasm
- Hedgehog Proteins
- Humans
- Mutation
- Neoadjuvant Therapy
- Pyridines