Hedgehog signaling pathway as a target for therapeutic intervention in basal cell carcinoma.

Abstract excerpt

Basal cell carcinomas (BCC) are slow-growing skin tumors that rarely metastasize but frequently recur, most often around the face, head and neck. Currently, surgery is the only treatment practice, which can be painful and leave scars. However, several years ago it was discovered that almost all forms of BCC result from mutations in a signaling pathway controlled by a protein called Hedgehog (Hh). Recently, a...

Topics

• Animals
• Antineoplastic Agents
• Carcinoma, Basal Cell
• Carrier Proteins
• Dioxoles
• Humans
• Membrane Glycoproteins
• Mutation
• Piperazines
• Signal Transduction
• Skin Neoplasms