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Article

Basal cell carcinoma pathogenesis and therapy involving hedgehog signaling and beyond.

Molecular carcinogenesis - 1 Dec 2017

Bakshi Anshika, Chaudhary Sandeep C, Rana Mehtab, Elmets Craig A, Athar Mohammad

Abstract excerpt

Basal cell carcinoma (BCC) of the skin is driven by aberrant hedgehog signaling. Thus blocking this signaling pathway by small molecules such as vismodegib inhibits tumor growth. Primary cilium in the epidermal cells plays an integral role in the processing of hedgehog signaling-related proteins. Recent genomic studies point to the involvement of additional genetic mutations that might be associated with the...

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Identifiers

PMID: 28574612
DOI: 10.1002/mc.22690
PMCID: PMC5962346

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SMO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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