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Article

Integrin α8 and Pcdh15 act as a complex to regulate cilia biogenesis in sensory cells.

Journal of cell science - 1 Nov 2017

Goodman Linda, Zallocchi Marisa

Abstract excerpt

The way an organism perceives its surroundings depends on sensory systems and the highly specialized cilia present in the neurosensory cells. Here, we describe the existence of an integrin α8 (Itga8) and protocadherin-15a (Pcdh15a) ciliary complex in neuromast hair cells in a zebrafish model. Depletion of the complex via downregulation or loss-of-function mutation leads to a dysregulation of cilia biogenesis and...

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Source

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Identifiers

PMID: 28883094
DOI: 10.1242/jcs.206201
PMCID: PMC5702057

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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