Article
Prostacyclin, thromboxane and glomerular filtration rate are abnormal in sickle cell pregnancy.
PloS one - 1 Jan 2017
Obilade Opeyemi Abayomi, Akanmu Alani Suleimon, Broughton Pipkin Fiona, Afolabi Bosede Bukola
Abstract excerpt
BACKGROUND: Pregnancy increases the risk of morbidity and mortality in sickle cell disease. We previously showed pregnant women with sickle cell disease to have a relatively low plasma renin concentration in late pregnancy, associated with a lack of the expected plasma volume expansion. We hypothesized this to be due to increased systemic vascular resistance through an imbalance between the vasodilator...
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