Article
Polymorphism in IKZF1 gene affects clinical outcome in diffuse large B-cell lymphoma.
International journal of hematology - 1 Dec 2017
Bielska Marta, Borowiec Maciej, Jesionek-Kupnicka Dorota, Braun Marcin, Bojo Marcin, Pastorczak Agata, Kalinka-Warzocha Ewa, Prochorec-Sobieszek Monika, Robak Tadeusz, Warzocha Krzysztof, Młynarski Wojciech, Lech-Marańda Ewa
Abstract excerpt
IKZF1 encodes a transcription factor involved in B-cell maturation and differentiation. We genotyped 218 diffuse large B-cell lymphoma (DLBCL) patients and 715 unrelated controls using a TaqMan allelic discrimination assay. No statistical difference was observed in the genotype distribution of the IKZF1 rs4132601 polymorphism between DLBCL patients and controls. However, the 2-year PFS rate of patients with the...
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