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Article

Identification of a 35S U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complex intermediate in spliceosome assembly.

The Journal of biological chemistry - 3 Nov 2017

Chen Zhe, Gui Bin, Zhang Yu, Xie Guojia, Li Wanjin, Liu Shumeng, Xu Bosen, Wu Chongyang, He Lin, Yang Jianguo, Yi Xia, Yang Xiaohan, Sun Luyang, Liang Jing, Shang Yongfeng

Abstract excerpt

The de novo assembly and post-splicing reassembly of the U4/U6.U5 tri-snRNP remain to be investigated. We report here that ZIP, a protein containing a CCCH-type zinc finger and a G-patch domain, as characterized by us previously, regulates pre-mRNA splicing independent of RNA binding. We found that ZIP physically associates with the U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP). Remarkably, the...

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Identifiers

PMID: 28878014
DOI: 10.1074/jbc.M117.797357
PMCID: PMC5672036

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