Article

Schwann cell dysfunction contributes to diabetic wound pathology which is partially ameliorated by oncostatin M treatment

2026-02-25

Abstract excerpt

<h4>ABSTRACT</h4> Chronic diabetic wounds represent a major clinical burden and are strongly associated with peripheral neuropathy, yet the contribution of nerve-associated Schwann cells to impaired healing remains poorly defined. Here, we investigated Schwann cell dynamics in cutaneous wound repair using the db / db model of type 2 diabetes. Full-thickness excisional wounds in db / db mice exhibited delayed...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a5dc6c32-08dd-56cb-a165-031e19691870
DOI: 10.64898/2026.02.24.707760

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Schwann cell dysfunction contributes to diabetic wound pathology which is partially ameliorated by oncostatin M treatmentDOI 10.64898/2026.02.24.707760Read

Multi-omics analysis of type II diabetic wound healing reveals CD44-mediated immune cell crosstalk dysfunction in mice and humansSemantic proximity Read

The molecular signature of impaired diabetic wound healing identifies serpinB3 as a healing biomarkerSemantic proximity Read

iPSC-derived exosomes promote diabetic wound healing by attenuating inflammatory responsesSemantic proximity Read

4D multimodal wound healing atlas reveals organ-level controls of repair phase transitionsSemantic proximity Read

Single-cell RNA sequencing reveals the impaired epidermal differentiation and pathological microenvironment in diabetic foot ulcerSemantic proximity Read

Cellular Senescence as the Pathogenic Hub of Diabetes-Related Wound ChronicitySemantic proximity Read

Characterizing Fibroblast Heterogeneity in Diabetic Wounds Through Single-Cell RNA-SequencingSemantic proximity Read

Exploring microRNAs in diabetic chronic cutaneous ulcers: Regulatory mechanisms and therapeutic potentialSemantic proximity Read

Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healingSemantic proximity Read

The Role of Omics Techniques in Diabetic Wound Healing: Recent Insights into the Application of Single-Cell RNA Sequencing, Bulk RNA Sequencing, Spatial Transcriptomics, and ProteomicsSemantic proximity Read

Longitudinal <i>in vivo</i> human wound healing model defines key role for smooth muscle cells in ECM remodelingSemantic proximity Read

Alteration of nociceptive Schwann cells in a mouse model of high-fat diet induced diabetic peripheral neuropathySemantic proximity Read