Article
The Global Regulatory Cyclic AMP Receptor Protein (CRP) Controls Multifactorial Fluoroquinolone Susceptibility in Salmonella enterica Serovar Typhimurium.
Antimicrobial agents and chemotherapy - 1 Nov 2017
Kary Stefani C, Yoneda Joshua R K, Olshefsky Stephen C, Stewart Laura A, West Steven B, Cameron Andrew D S
Abstract excerpt
Fluoroquinolone antibiotics are prescribed for the treatment of Salmonella enterica infections, but resistance to this family of antibiotics is growing. Here we report that loss of the global regulatory protein cyclic AMP (cAMP) receptor protein (CRP) or its allosteric effector, cAMP, reduces susceptibility to fluoroquinolones. A Δcrp mutation was synergistic with the primary fluoroquinolone resistance allele...
Topics
- Adenosine Triphosphate
- Anti-Bacterial Agents
- Bacterial Outer Membrane Proteins
- Bacterial Proteins
- Ciprofloxacin
- DNA Gyrase
- DNA, Bacterial
- Drug Resistance, Multiple, Bacterial
- Fluoroquinolones