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Article

CRP regulator modulates multidrug resistance of Escherichia coli by repressing the mdtEF multidrug efflux genes.

The Journal of antibiotics - 1 Mar 2008

Nishino Kunihiko, Senda Yasuko, Yamaguchi Akihito

Abstract excerpt

Multidrug efflux pumps contribute to the resistance of Escherichia coli against many antibiotics and biocides. Here, we report that the CRP regulator modulates multidrug resistance in E. coli through repression of the genes encoding the MdtEF multidrug efflux pump. Screening of mutants for ability to increase beta-lactam resistance in E. coli led to the identification of a mutation in crp, which codes for the...

Topics

ATP Binding Cassette Transporter, Subfamily B
Anti-Bacterial Agents
Drug Resistance, Multiple, Bacterial
Escherichia coli
Escherichia coli Proteins
Gene Deletion
Genes, MDR
Membrane Transport Proteins
Microbial Sensitivity Tests
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oxacillin

Plasmids

RNA, Bacterial

Reverse Transcriptase Polymerase Chain Reaction

Source

Identifiers

PMID: 18503189
DOI: 10.1038/ja.2008.120

Genes

CRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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