Article
The genomic landscape of human cellular circadian variation points to a novel role for the signalosome.
eLife - 4 Sept 2017
Gaspar Ludmila, Howald Cedric, Popadin Konstantin, Maier Bert, Mauvoisin Daniel, Moriggi Ermanno, Gutierrez-Arcelus Maria, Falconnet Emilie, Borel Christelle, Kunz Dieter, Kramer Achim, Gachon Frederic, Dermitzakis Emmanouil T, Antonarakis Stylianos E, Brown Steven A
Abstract excerpt
The importance of natural gene expression variation for human behavior is undisputed, but its impact on circadian physiology remains mostly unexplored. Using umbilical cord fibroblasts, we have determined by genome-wide association how common genetic variation impacts upon cellular circadian function. Gene set enrichment points to differences in protein catabolism as one major source of clock variation in humans....
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