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Article

Mechanisms underlying human genetic diversity: consequence for antigraft antibody responses.

Transplant international : official journal of the European Society for Organ Transplantation - 1 Mar 2018

Reindl-Schwaighofer Roman, Heinzel Andreas, Signorini Lorenzo, Thaunat Olivier, Oberbauer Rainer

Abstract excerpt

This review focuses on the emerging concept of genomewide genetic variation as basis of an alloimmune response. Chronic antibody-mediated rejection is the major cause of long-term graft loss and growing evidence supports the clinical relevance of HLA but also non-HLA related alloimmune responses. Several polymorphic gene products have been identified as minor histocompatibility antigens. The formation of...

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Source

Identifiers

PMID: 28865128
DOI: 10.1111/tri.13059

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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