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Article

Discovery of a novel lantibiotic nisin O from Blautia obeum A2-162, isolated from the human gastrointestinal tract.

Microbiology (Reading, England) - 1 Sept 2017

Hatziioanou Diane, Gherghisan-Filip Cristina, Saalbach Gerhard, Horn Nikki, Wegmann Udo, Duncan Sylvia H, Flint Harry J, Mayer Melinda J, Narbad Arjan

Abstract excerpt

A novel lanC-like sequence was identified from the dominant human gut bacterium Blautia obeum strain A2-162. This sequence was extended to reveal a putative lantibiotic operon with biosynthetic and transport genes, two sets of regulatory genes, immunity genes, three identical copies of a nisin-like lanA gene with an unusual leader peptide, and a fourth putative lanA gene. Comparison with other nisin clusters...

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Identifiers

PMID: 28857034
DOI: 10.1099/mic.0.000515
PMCID: PMC5882112

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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