Article
TCR-like antibodies mediate complement and antibody-dependent cellular cytotoxicity against Epstein-Barr virus-transformed B lymphoblastoid cells expressing different HLA-A*02 microvariants.
Scientific reports - 30 Aug 2017
Lai Junyun, Choo Joanna Ai Ling, Tan Wei Jian, Too Chien Tei, Oo Min Zin, Suter Manuel A, Mustafa Fatimah Bte, Srinivasan Nalini, Chan Conrad En Zuo, Lim Andrew Guo Xian, Zhong Youjia, Chan Soh Ha, Hanson Brendon J, Gascoigne Nicholas R J, MacAry Paul A
Abstract excerpt
Epstein-Barr virus (EBV) is a common gammaherpesvirus associated with various human malignancies. Antibodies with T cell receptor-like specificities (TCR-like mAbs) provide a means to target intracellular tumor- or virus-associated antigens by recognising their processed peptides presented on major histocompatibility complex (MHC) class I (pMHC) complexes. These antibodies are however thought to be relevant only...
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