Article
Genetic diversity among pandemic 2009 influenza viruses isolated from a transmission chain.
Virology journal - 12 Apr 2013
Fordyce Sarah L, Bragstad Karoline, Pedersen Svend Stenvang, Jensen Thøger G, Gahrn-Hansen Bente, Daniels Rod, Hay Alan, Kampmann Marie-Louise, Bruhn Christian A W, Moreno-Mayar J Victor, Ávila-Arcos María C, Gilbert M Thomas P, Nielsen Lars P
Abstract excerpt
BACKGROUND: Influenza viruses such as swine-origin influenza A(H1N1) virus (A(H1N1)pdm09) generate genetic diversity due to the high error rate of their RNA polymerase, often resulting in mixed genotype populations (intra-host variants) within a single infection. This variation helps influenza to rapidly respond to selection pressures, such as those imposed by the immunological host response and antiviral...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.