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Article

Cardiolipin Synthesis and Outer Membrane Localization Are Required for Shigella flexneri Virulence.

mBio - 29 Aug 2017

Rossi Rachael M, Yum Lauren, Agaisse Hervé, Payne Shelley M

Abstract excerpt

Cardiolipin, an anionic phospholipid that resides at the poles of the inner and outer membranes, is synthesized primarily by the putative cardiolipin synthase ClsA in Shigella flexneri An S. flexneri clsA mutant had no cardiolipin detected within its membrane, grew normally in vitro, and invaded cultured epithelial cells, but it failed to form plaques in epithelial cell monolayers, indicating that cardiolipin is...

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Identifiers

PMID: 28851846
DOI: 10.1128/mBio.01199-17
PMCID: PMC5574711

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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