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Article

A cartridge-based assay for improved detection of multidrug-resistant Mycobacterium tuberculosis directly from sputum.

Journal of clinical microbiology - 13 May 2026

Rudra Paulami, Parmar Heta, Daivaa Naranjargal, Tran Claire, Narang Anshika, Singh Simranjit, Somaiya Dhara, Roybardhan Samarpita, Anwesa Ritu, Reiss Robert, Ward Shawn, Penn-Nicholson Adam, De Vos Margaretha, Armstrong Derek T, Borkman April L, Ellner Jerrold, Dorman Susan E, Kim Soyeon, Yuan Lin, Alland David, Chakravorty Soumitesh

Abstract excerpt

Tuberculosis (TB) is a global health threat complicated by increasing INH resistance (INH-R) and rifampicin resistance (RIF-R), including RIF-R due to rpoB Ile491Phe (I491F) mutations, which are not detected by current molecular resistance tests. We developed a low-complexity automated nucleic acid amplification test MDRmDx, designed to operate on the 10-color GeneXpert instrument, which detects Mycobacterium...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41910325
DOI: 10.1128/jcm.01100-25
PMCID: PMC13170168

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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