Article
The pivotal role of matrix metalloproteinases in the development of human abdominal aortic aneurysms.
Vascular medicine (London, England) - 1 Nov 2003
Liapis Christos D, Paraskevas Kosmas I
Abstract excerpt
Abdominal aortic aneurysms (AAAs) represent a chronic degenerative condition and impart the risk of a life-threatening episode of rupture. Chronic inflammation and destructive remodeling of the extracellular matrix of the aortic wall constitute trademarks of this entity. Multiple studies have implicated a group of locally produced matrix endopeptidases-the matrix metalloproteinases (MMPs)-as the main culprits of...
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