Integrated Computational Analysis of Genes Associated with Human Hereditary Insensitivity to Pain. A Drug Repurposing Perspective

Abstract excerpt

Genes causally involved in human insensitivity to pain provide a unique molecular source of studying the pathophysiology of pain and the development of novel analgesic drugs. The increasing availabil-ity of “big data” enables novel research approaches to chronic pain while also requiring novel tech-niques for data mining and knowledge discovery. We used machine learning to combine the knowledge about n = 20 genes...

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