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Article

Desipramine rescues age-related phenotypes in depression-like rats induced by chronic mild stress.

Life sciences - 1 Nov 2017

Xie Xiaoxian, Chen Yangyang, Wang Qi, Shen Qichen, Ma Lingyan, Huang Liangfeng, Wu Tao, Fu Zhengwei

Abstract excerpt

AIMS: Our previous finding demonstrates that major depressive disorder can mediate accelerated aging in rats. Desipramine is a typical tricyclic antidepressant, and can provide neuroprotection and counteract depression-like behaviors. However, whether desipramine can rescue age-related phenotypes in depressed individuals is not understood. In the present study, we investigated the physiological function of...

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Identifiers

PMID: 28842312
DOI: 10.1016/j.lfs.2017.08.020

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FST
TERT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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