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Article

Telomerase Dysregulation in the Hippocampus of a Rat Model of Depression: Normalization by Lithium

24 Jan 2015

Abstract excerpt

BACKGROUND: Telomeres are protective DNA-protein complexes at the ends of each chromosome, maintained primarily by the enzyme telomerase. Shortening of the blood leukocyte telomeres is associated with aging, several chronic diseases, and stress, eg, major depression. Hippocampus is pivotal in the regulation of cognition and mood and the main brain region of telomerase activity. Whether there is telomere...

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Share to Epigenetics and DNA Methylation
Share to Menopause: Health Impacts and Treatments
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PMID: 25618407
DOI: 10.1093/ijnp/pyv002

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