Article
Single nucleotide variations in cultured cancer cells: Effect of mismatch repair.
Mutation research - 1 Oct 2017
Panyutin Igor G, Panyutin Irina V, Powell-Castilla Ian, Felix Laura, Neumann Ronald D
Abstract excerpt
We assessed single nucleotide variations (SNVs) between individual cells in two cancer cell lines; DU145, from brain metastasis of prostate tumor with deficient mismatch repair; and HT1080, a fibrosarcoma cell line. Clones of individual cells were isolated, and sequenced using Ion Ampliseq comprehensive cancer panel that covered the exomes of 409 oncogenes and tumor suppressor genes. Five clones of DU145 and four...
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