Article
A natural history of melanomas and dysplastic nevi: an atlas of lesions in melanoma-prone families.
Cancer - 15 Jun 2002
Tucker Margaret A, Fraser Mary C, Goldstein Alisa M, Struewing Jeffery P, King Mary A, Crawford John T, Chiazze Ellen A, Zametkin Deborah P, Fontaine Laura S, Clark Wallace H
Abstract excerpt
BACKGROUND: Few long-term clinical and histologic data for melanocytic lesions have been available based on the mutation status of families at an increased risk of melanoma. In the current study, the authors describe the clinical and histologic features of dysplastic nevi and melanoma over time in families at an increased risk of melanoma with differing germline mutations in CDKN2A, CDK4, or not yet identified...
Topics
- Cyclin-Dependent Kinase 4
- Cyclin-Dependent Kinases
- Dysplastic Nevus Syndrome
- Genes, p16
- Humans
- Melanoma
- Mutation
- Prospective Studies
- Proto-Oncogene Proteins
- Self-Examination