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HSPB7 prevents cardiac conduction system defect through maintaining intercalated disc integrity

21 Aug 2017

Abstract excerpt

HSPB7 is a member of the small heat-shock protein (HSPB) family and is expressed in the cardiomyocytes from cardiogenesis onwards. A dramatic increase in HSPB7 is detected in the heart and blood plasma immediately after myocardial infarction. Additionally, several single-nucleotide polymorphisms of HSPB7 have been identified to be associated with heart failure caused by cardiomyopathy in human patients. Although...

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PMID: 28827800
DOI: 10.1371/journal.pgen.1006984

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