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Article

Identification of an Interleukin 17F/17A Heterodimer in Activated Human CD4+ T Cells

13 Mar 2007

Abstract excerpt

IL-17F and IL-17A are members of the IL-17 pro-inflammatory cytokine family. IL-17A has been implicated in the pathogenesis of autoimmune diseases. IL-17F is a disulfide-linked dimer that contains a cysteine-knot motif. We hypothesized that IL-17F and IL-17A could form a heterodimer due to their sequence homology and overlapping pattern of expression. We evaluated the structure of recombinant IL-17F and IL-17A...

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Identifiers

PMID: 17355969
DOI: 10.1074/jbc.m700499200

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