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Article

Amelogenin induces M2 macrophage polarisation via PGE2/cAMP signalling pathway.

Archives of oral biology - 1 Nov 2017

Yamamichi Kensuke, Fukuda Takao, Sanui Terukazu, Toyoda Kyosuke, Tanaka Urara, Nakao Yuki, Yotsumoto Karen, Yamato Hiroaki, Taketomi Takaharu, Uchiumi Takeshi, Nishimura Fusanori

Abstract excerpt

OBJECTIVES: Amelogenin, the major component of the enamel matrix derivative (EMD), has been suggested as a bioactive candidate for periodontal regeneration. Apart from producing a regenerative effect on periodontal tissues, amelogenin has also been reported to have an anti-inflammatory effect. However, the precise molecular mechanisms underlying these effects remain unclear. In the present study, we examined the...

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PMID: 28822800
DOI: 10.1016/j.archoralbio.2017.08.005

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EMD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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