Article
PknB remains an essential and a conserved target for drug development in susceptible and MDR strains of M. Tuberculosis.
Annals of clinical microbiology and antimicrobials - 18 Aug 2017
Gupta Anamika, Pal Sudhir K, Pandey Divya, Fakir Najneen A, Rathod Sunita, Sinha Dhiraj, SivaKumar S, Sinha Pallavi, Periera Mycal, Balgam Shilpa, Sekar Gomathi, UmaDevi K R, Anupurba Shampa, Nema Vijay
Abstract excerpt
BACKGROUND: The Mycobacterium tuberculosis (M.tb) protein kinase B (PknB) which is now proved to be essential for the growth and survival of M.tb, is a transmembrane protein with a potential to be a good drug target. However it is not known if this target remains conserved in otherwise resistant isolates from clinical origin. The present study describes the conservation analysis of sequences covering the...
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