Article
Proteogenomic Investigation of Strain Variation in Clinical Mycobacterium tuberculosis Isolates.
Journal of proteome research - 6 Oct 2017
Heunis Tiaan, Dippenaar Anzaan, Warren Robin M, van Helden Paul D, van der Merwe Ruben G, Gey van Pittius Nicolaas C, Pain Arnab, Sampson Samantha L, Tabb David L
Abstract excerpt
Mycobacterium tuberculosis consists of a large number of different strains that display unique virulence characteristics. Whole-genome sequencing has revealed substantial genetic diversity among clinical M. tuberculosis isolates, and elucidating the phenotypic variation encoded by this genetic diversity will be of the utmost importance to fully understand M. tuberculosis biology and pathogenicity. In this study,...
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