Nucleic acid-mediated inflammatory diseases.

Abstract excerpt

Enzymes that degrade nucleic acids are emerging as important players in the pathogenesis of inflammatory disease. This is exemplified by the recent identification of four genes that cause the childhood inflammatory disorder, Aicardi-Goutières syndrome (AGS). This is an autosomal recessive neurological condition whose clinical and immunological features parallel those of congenital viral infection. The four AGS...

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• Syndrome
• Autoimmunity
• Exodeoxyribonucleases
• Immunity, Innate
• Inflammation