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Article

Structural transitions in conserved, ordered Beclin 1 domains essential to regulating autophagy.

The Journal of biological chemistry - 29 Sept 2017

Glover Karen, Li Yue, Mukhopadhyay Shreya, Leuthner Zoe, Chakravarthy Srinivas, Colbert Christopher L, Sinha Sangita C

Abstract excerpt

Beclin 1 (BECN1) is a key regulator of autophagy, a critical catabolic homeostasis pathway that involves sequestration of selected cytoplasmic components by multilayered vesicles called autophagosomes, followed by lysosomal fusion and degradation. BECN1 is a core component of class III phosphatidylinositol-3-kinase complexes responsible for autophagosome nucleation. Without heterologous binding partners, BECN1...

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Source

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Identifiers

PMID: 28798234
DOI: 10.1074/jbc.M117.804195
PMCID: PMC5625053

Genes

BECN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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