Article
Mutation status of RAD51C, PALB2 and BRIP1 in 100 Japanese familial breast cancer cases without BRCA1 and BRCA2 mutations.
Cancer science - 1 Nov 2017
Sato Katsutoshi, Koyasu Mio, Nomura Sachio, Sato Yuri, Kita Mizuho, Ashihara Yuumi, Adachi Yasue, Ohno Shinji, Iwase Takuji, Kitagawa Dai, Nakashima Eri, Yoshida Reiko, Miki Yoshio, Arai Masami
Abstract excerpt
In addition to BRCA1 and BRCA2, RAD51C, PALB2 and BRIP1 are known as breast cancer susceptibility genes. However, the mutation status of these genes in Japanese familial breast cancer cases has not yet been evaluated. To this end, we analyzed the exon sequence and genomic rearrangement of RAD51C, PALB2 and BRIP1 in 100 Japanese patients diagnosed with familial breast and ovarian cancer and without BRCA1 and BRCA2...
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