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Article

DCTN1 gene analysis in Chinese patients with sporadic amyotrophic lateral sclerosis.

PloS one - 1 Jan 2017

Liu Xiangyi, Yang Lipeng, Tang Lu, Chen Lu, Liu Xiaolu, Fan Dongsheng

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder. Missense mutations of DCTN1 have been identified as a possible genetic risk factor for ALS. Here, we tested the DCTN1 protein-coding exons in 510 sporadic ALS patients in whom SOD1, TARDBP, FUS, and C9orf72 genes were screened before. Polymerase chain reaction and Sanger sequencing were used for mutation discovery. The results revealed two...

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Source

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Identifiers

PMID: 28792508
DOI: 10.1371/journal.pone.0182572
PMCID: PMC5549744

Genes

DCTN1
FUS
SOD1
TARDBP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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