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Article

Wee1 Kinase Inhibitor AZD1775 Radiosensitizes Hepatocellular Carcinoma Regardless of TP53 Mutational Status Through Induction of Replication Stress.

International journal of radiation oncology, biology, physics - 1 Jun 2016

Cuneo Kyle C, Morgan Meredith A, Davis Mary A, Parcels Leslie A, Parcels Joshua, Karnak David, Ryan Caila, Liu Na, Maybaum Jonathan, Lawrence Theodore S

Abstract excerpt

PURPOSE: Wee1 kinase inhibitors are effective radiosensitizers in cells lacking a G1 checkpoint. In this study we examined the potential effect of Wee1 kinase inhibition on inducing replication stress in hepatocellular carcinoma (HCC). METHODS AND MATERIALS: Five independent datasets from the Oncomine database comparing gene expression in HCC compared to normal tissue were combined and specific markers associated...

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Identifiers

PMID: 26975930
DOI: 10.1016/j.ijrobp.2016.01.028
PMCID: PMC6644066

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CDK1

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Wee1 Kinase Inhibitor AZD1775 Radiosensitizes Hepatocellular Carcinoma Regardless of TP53 Mutational Status Through Induction of Replication Stress.PMID 26975930Read ↗

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