Article
A novel prognostic model incorporating genetic profiling for myelodysplastic syndromes.
[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Jan 2017
Nagata Yasunobu, Ogawa Seishi
Abstract excerpt
Targeted and unbiased next-generation sequencing (NGS) has contributed to a better understanding of the molecular pathogenesis of myeloid neoplasms, including MDS. Discovery efforts have identified novel classes of mutated genes, while deep NGS approaches have yielded a better appreciation of clonal hierarchy, intercase variability, and intratumor heterogeneity. However, comprehensive analyses of sequences of...
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