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Prognostic impact of next-generation sequencing on myelodysplastic syndrome: A single-center experience.

Medicine - 11 Oct 2024

Bülbül Hale, Kaya Özge Özer, Karadağ Fatma Keklik, Olgun Aybüke, Demirci Zühal, Ceylan Cengiz

Abstract excerpt

Myelodysplastic syndromes (MDS) are clinically heterogeneous disorders characterized by peripheral blood cytopenias, poor differentiation, clonal hematopoiesis, and increased risk of developing acute myeloid leukemia (AML). While somatic mutations do not currently feature in prognostic scoring systems, they may impact the clinical phenotype. In recent years, next-generation sequencing (NGS) has enabled the...

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Identifiers

PMID: 39465815
DOI: 10.1097/MD.0000000000039909
PMCID: PMC11479520

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