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Article

Deep sequencing of RSV from an adult challenge study and from naturally infected infants reveals heterogeneous diversification dynamics.

Virology - 1 Oct 2017

Lau Jessica W, Kim Young-In, Murphy Ryan, Newman Ruchi, Yang Xiao, Zody Michael, DeVincenzo John, Grad Yonatan H

Abstract excerpt

As RNA virus mutation occurs during replication within host cells, we hypothesized that viral evolution during acute infections in healthy hosts reflects host immune pressure. We therefore investigated the within-host diversification of human respiratory syncytial virus (RSV), a highly prevalent cause of acute respiratory infections. We evaluated healthy adults experimentally infected with an identical inoculum...

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Identifiers

PMID: 28779686
DOI: 10.1016/j.virol.2017.07.017
PMCID: PMC5580249

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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