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Article

Identification of candidate protective variants for common diseases and evaluation of their protective potential.

BMC genomics - 3 Aug 2017

Butler Joe M, Hall Neil, Narendran Niro, Yang Yit C, Paraoan Luminita

Abstract excerpt

BACKGROUND: Human polymorphisms with derived alleles that are protective against disease may provide powerful translational opportunities. Here we report a method to identify such candidate polymorphisms and apply it to common non-synonymous SNPs (nsSNPs) associated with common diseases. Our study also sought to establish which of the identified protective nsSNPs show evidence of positive selection, taking this...

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Identifiers

PMID: 28774272
DOI: 10.1186/s12864-017-3964-3
PMCID: PMC5543444

Genes

LPL
CFB

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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