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Article

Endostatin sensitizes p53‐deficient non‐small‐cell lung cancer to genotoxic chemotherapy by targeting DNA‐dependent protein kinase catalytic subunit

3 Aug 2017

Abstract excerpt

Endostatin was discovered as an endogenous angiogenesis inhibitor with broad-spectrum antitumour activities. Although clinical efficacy was observed when endostatin was combined with standard chemotherapy for non-small cell lung cancer (NSCLC), as well as other cancer types, the specific mechanisms underlying the benefit of endostatin are not completely understood. Extensive investigations suggest that endostatin...

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PMID: 28771739
DOI: 10.1002/path.4952

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