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Article

Rare transformation to double hit lymphoma in Waldenstrom's macroglobulinemia.

Immunotherapy - 1 Aug 2017

Okolo Onyemaechi N, Johnson Ariel C, Yun Seongseok, Arnold Stacy J, Anwer Faiz

Abstract excerpt

Waldenström macroglobulinemia (WM) is a lymphoproliferative lymphoma that is characterized by monoclonal immunoglobulin M (IgM) protein and bone marrow infiltration. Its incidence is rare and rarer still is its ability to transform to a B-cell lymphoma, particularly the aggressive diffuse large B-cell lymphoma, which bodes a poor prognosis. When transformation includes mutations of MYC, BCL-2 and/or BCL-6, it is...

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Topics

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Share to Bone Marrow
Share to Cell Transformation, Neoplastic
Share to Immunoglobulin M

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunophenotyping

Share to Lymphoma, B-Cell

Share to Proto-Oncogene Proteins c-bcl-2

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Share to Waldenstrom Macroglobulinemia

Source

Open in PubMed Open full text

Identifiers

PMID: 28771100
DOI: 10.2217/imt-2017-0027
PMCID: PMC5992568

Genes

MYC
BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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