Article
Evaluation and Management of Disease Transformation in Waldenström Macroglobulinemia.
Hematology/oncology clinics of North America - 1 Aug 2023
Talaulikar Dipti, Tomowiak Cécile, Toussaint Elise, Morel Pierre, Kapoor Prashant, Castillo Jorge J, Delmer Alain, Durot Eric
Abstract excerpt
Histologic transformation (HT) to diffuse large B-cell lymphoma occurs rarely in Waldenström macroglobulinemia, with higher incidence in MYD88 wild-type patients. HT is suspected clinically when rapidly enlarging lymph nodes, elevated lactate dehydrogenase levels, or extranodal disease occur. Histologic assessment is required for diagnosis. HT carries a worse prognosis compared with nontransformed Waldenström...
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