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Article

Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 low pathogenicity avian influenza virus.

Nature communications - 19 Nov 2024

Sun Ju, Zheng Tianyi, Jia Mingjun, Wang Yanjun, Yang Jingru, Liu Yun, Yang Pengyun, Xie Yufeng, Sun Honglei, Tong Qi, Li Jiaming, Yang Jing, Fu Guanghua, Shi Yi, Qi Jianxun, Liu Wenjun, Liu Jinhua, Tian Wen-Xia, Gao George F, Bi Yuhai

Abstract excerpt

The 1957 H2N2 influenza pandemic virus [A(H2N2)pdm1957] has disappeared from humans since 1968, while H2N2 avian influenza viruses (AIVs) are still circulating in birds. It is necessary to reveal the recurrence risk and potential cross-species infection of these AIVs from avian to mammals. We find that H2 AIVs circulating in domestic poultry in China have genetic and antigenic differences compared to the...

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PMID: 39562538
DOI: 10.1038/s41467-024-54374-z
PMCID: PMC11576999

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