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Article

NOD2 gene variants confer risk for secondary sclerosing cholangitis in critically ill patients.

Scientific reports - 1 Aug 2017

Jüngst Christoph, Stadlbauer Vanessa, Reichert Matthias C, Zimmer Vincent, Weber Susanne N, Ofner-Ziegenfuß Lisa, Voigtländer Torsten, Spindelböck Walter, Fickert Peter, Kirchner Gabriele I, Lammert Frank, Lankisch Tim O, Krawczyk Marcin

Abstract excerpt

Sclerosing cholangitis in critically ill patients (SC-CIP) is a progressive cholestatic disease of unknown aetiology characterized by chronic biliary infections. Hence we hypothesized that common NOD2 (nucleotide-binding oligomerisation domain containing 2) gene variants, known risk factors for Crohn's disease and bacterial translocation in liver cirrhosis, increase the odds of developing SC-CIP. Screening of...

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Cholangitis, Sclerosing
Critical Illness
NOD2 gene
Genetic Predisposition to Disease
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nod2 Signaling Adaptor Protein

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Identifiers

PMID: 28765628
DOI: 10.1038/s41598-017-06268-y
PMCID: PMC5539147

Genes

NOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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