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Article

Nucleotide‐binding oligomerization domain containing 2 (NOD2) variants are genetic risk factors for death and spontaneous bacterial peritonitis in liver cirrhosis†

20 Nov 2009

Abstract excerpt

UNLABELLED: Spontaneous bacterial peritonitis (SBP), a severe complication in patients with advanced liver cirrhosis, has been attributed to bacterial translocation from the intestine. Variants of the NOD2 (nucleotide-binding oligomerization domain containing 2) gene have been associated with impaired mucosal barrier function in Crohn disease. We hypothesized that the risk of acquiring SBP is increased in...

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Barrier Structure and Function Studies
Immune Response and Inflammation
Liver Disease and Transplantation

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 20087966
DOI: 10.1002/hep.23440

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Nucleotide‐binding oligomerization domain containing 2 (NOD2) variants are genetic risk factors for death and spontaneous bacterial peritonitis in liver cirrhosis†PMID 20087966Read ↗

NOD2 gene variants are a risk factor for culture-positive spontaneous bacterial peritonitis and monomicrobial bacterascites in cirrhosis.Semantic proximity Read ↗

Nucleotide-Binding Oligomerization Domain-Containing Protein 2 Variants in Patients with Spontaneous Bacterial Peritonitis.Semantic proximity Read ↗

Toll-like receptor (TLR) 2 promoter and intron 2 polymorphisms are associated with increased risk for spontaneous bacterial peritonitis in liver cirrhosis.Semantic proximity Read ↗

NOD2 gene variants confer risk for secondary sclerosing cholangitis in critically ill patients.Semantic proximity Read ↗

The INCA trial (Impact of NOD2 genotype-guided antibiotic prevention on survival in patients with liver Cirrhosis and Ascites): study protocol for a randomized controlled trial.Semantic proximity Read ↗

Functional polymorphisms of innate immunity receptors are not risk factors for the non-SBP type bacterial infections in cirrhosis.Semantic proximity Read ↗

A variant in the nuclear dot protein 52kDa gene increases the risk for spontaneous bacterial peritonitis in patients with alcoholic liver cirrhosis.Semantic proximity Read ↗

The prognostic power of the NOD2 genotype for complicated Crohn's disease: a meta-analysis.Semantic proximity Read ↗

Presence of NOD2 mutations is not associated with hepatic or systemic hemodynamic abnormalities of cirrhosis.Semantic proximity Read ↗

Exploring the Relationship Between NOD2 Risk Variants and First Decompensation Events in Cirrhotic Patients With Varices.Semantic proximity Read ↗

NOD2 gene variant is a risk factor for postoperative complications in patients with Crohn's disease: A genetic association study.Semantic proximity Read ↗

[The INCA trial (impact of NOD2 genotype-guided antibiotic prevention on survival in patients with liver cirrhosis and ascites): precision medicine for patients with liver cirrhosis and ascites].Semantic proximity Read ↗

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