Article
Imatinib-induced ophthalmological side-effects in GIST patients are associated with the variations of EGFR, SLC22A1, SLC22A5 and ABCB1.
The pharmacogenomics journal - 22 May 2018
Qiu H-B, Zhuang W, Wu T, Xin S, Lin C-Z, Ruan H-L, Zhu X, Huang M, Li J-L, Hou X-Y, Zhou Z-W, Wang X-D
Abstract excerpt
Imatinib-induced ophthalmological side-effects, including conjunctiva hemorrhage and periorbital oedema, although very common and still remain relatively little understood. The present study investigated the effects of genetic polymorphisms of drug targets and membrane transporters on these side effects. We found that the minor allele of EGFR rs10258429 and SLC22A1 rs683369 were significant risk determinants of...
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