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Article

Neuronal cytoskeletal gene dysregulation and mechanical hypersensitivity in a rat model of Rett syndrome.

Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 2017

Bhattacherjee Aritra, Mu Ying, Winter Michelle K, Knapp Jennifer R, Eggimann Linda S, Gunewardena Sumedha S, Kobayashi Kazuto, Kato Shigeki, Krizsan-Agbas Dora, Smith Peter G

Abstract excerpt

Children with Rett syndrome show abnormal cutaneous sensitivity. The precise nature of sensory abnormalities and underlying molecular mechanisms remain largely unknown. Rats with methyl-CpG binding protein 2 (MeCP2) mutation, characteristic of Rett syndrome, show hypersensitivity to pressure and cold, but hyposensitivity to heat. They also show cutaneous hyperinnervation by nonpeptidergic sensory axons, which...

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Identifiers

PMID: 28760966
DOI: 10.1073/pnas.1618210114
PMCID: PMC5565404

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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