The RNA-binding protein CELF4 is a negative regulator of sensory neuron excitability and mechanical and heat behavioral sensitivity

Abstract excerpt

• This paper addresses the function of the mRNA translation regulator, CELF4, in behavioral sensitivity, hyperalgesia, and sensory neuron excitability. • We show that this RNA-binding protein is a robust tonic negative regulator of nociceptor excitability, that may act as an endogenous brake on the development of hyperalgesia • Targeting CELF4 may lead to the discovery of mechanisms that regulate...

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