Cholera toxin discriminates between T helper 1 and 2 cells in T cell receptor-mediated activation: role of cAMP in T cell proliferation.

doi:10.1084/jem.172.1.95

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Article

Cholera toxin discriminates between T helper 1 and 2 cells in T cell receptor-mediated activation: role of cAMP in T cell proliferation.

The Journal of experimental medicine - 1 Jul 1990

Muñoz E, Zubiaga A M, Merrow M, Sauter N P, Huber B T

Abstract excerpt

CD4+ T helper (Th) clones can be divided into interleukin 2 (IL-2)-secreting Th1 and IL-4-secreting Th2 cells. We show in the present report that these two Th subsets have different activation requirements for lymphokine production and proliferation: namely, cholera toxin (CT) as well as forskoli...

Topics

Animals
Cell Division
Cell Line
Cholera Toxin
Colforsin
Cyclic AMP
Gene Expression
Interleukin-2
Interleukin-4
Lymphocyte Activation
Mice
Mice, Inbred AKR

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred BALB C

Phenotype

Proto-Oncogenes

RNA, Messenger

Receptors, Antigen, T-Cell

T-Lymphocytes, Helper-Inducer

Source

Open in PubMed Open full text

Identifiers

PMID: 2162906
DOI: 10.1084/jem.172.1.95
PMCID: PMC2188173

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2162906-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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