Article
Comprehensive Genomic Profiling of Renal Cell Carcinoma at Initial Diagnosis and Putative Local Recurrence.
European urology focus - 1 Mar 2018
Chalmers Zachary R, Johnson Adrienne, Ali Siraj M, Frampton Garrett M, Miller Vincent, Ross Jeffrey S, Pal Sumanta K
Abstract excerpt
In the context of metastatic renal cell carcinoma, it would typically be assumed that the site of recurrence is derived from the original tumor. Through the use of comprehensive genomic profiling in a case of localized disease with a subsequent recurrence in the renal fossa, we determined that the latter was a wholly distinct tumor. The original tumor harbors mutations in PBRM1, while the second harbors mutations...
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